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Buy JWH-018 Online
Buy JWH-018 Online; JWH-018 is a synthetic cannabinoid that was originally developed for research purposes in the mid-1990s by Dr. John W. Huffman, from whom it gets its name. Its chemical structure is part of the naphthoylindole family, and it acts as a potent agonist at the cannabinoid receptors CB1 and CB2 in the brain and body. These are the same receptors targeted by tetrahydrocannabinol (THC), the primary psychoactive compound in cannabis, but JWH-018 can bind more strongly, often resulting in more intense and unpredictable effects. Buy JWH-018 Online
Initially, JWH-018 was synthesized to study the endocannabinoid system and to better understand how cannabinoids interact with human physiology. However, in the late 2000s, it began appearing in herbal smoking mixtures marketed as “legal highs” or “synthetic marijuana.” These products were often sold under brand names like Spice or K2, with JWH-018 sprayed onto plant material for smoking.
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Because of its potency and potential for harmful side effects, JWH-018 quickly drew the attention of health authorities. Reported adverse effects have included anxiety, rapid heart rate, nausea, hallucinations, and in some cases, severe agitation or psychosis. Long-term health impacts remain poorly understood due to limited clinical research.
In response to safety concerns, many countries and states have classified JWH-018 as a controlled substance, making its production, sale, and possession illegal. Despite this, variations of its chemical structure (called “analogs”) have appeared in attempts to circumvent regulations. Buy JWH-018 Online
JWH-018 serves as a case study in how synthetic cannabinoids can move from laboratory research into unregulated markets, raising important public health and policy questions. While it played a role in advancing cannabinoid science, its unregulated recreational use has highlighted the risks of potent synthetic drugs with unknown long-term effects.
| Category | Details |
|---|---|
| Chemical Structure | Naphthalen-1-yl(1-pentyl-1H-indol-3-yl) methanone (structure shown above). UNODC |
| Synonyms / Alias | JWH-018, AM-678, 1-Pentyl-3-(1-naphthoyl)indole SafroleUNODC |
| CAS Number | 209414-07-3 UNODC |
| Molecular Formula | C₂₄H₂₃NO UNODC |
| Molecular Weight | 341.45 g/mol chemsrc.com |
| Physical Properties | White to off-white powder; melting point ~55–60 °C; soluble in organic solvents (e.g., DMSO, methanol), not water-soluble SafroleChemicalBook |
| Receptor Binding Affinity (Kᵢ) | CB₁: 9.00 ± 5.00 nM; CB₂: 2.94 ± 2.65 nM (indicating ~3× selectivity for CB₂) WikipediaScienceDirect |
| Functional Potency (EC₅₀) | Human CB₁: ~102 nM; CB₂: ~133 nM Wikipedia |
| In Vitro Binding Summary | JWH-018 displaces [³H]CP-55,940 at CB₁ with Kᵢ values in low nanomolar range, exhibiting up to 10-fold higher affinity than Δ⁹-THC (~1.2 nM vs. ~15 nM) PubMed CentralPubMed |
| Key Effects (Rodent Models) | Induces bradycardia and hypothermia at doses of 0.3–3 mg/kg, consistent with potent cannabinoid activity Wikipedia |
| QUANTITY | 50g, 100g, 200g, 500g, 1kg, 2kg, 5kg |
|---|
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Lewis (verified owner) –
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Thank you.
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All research products arrived safely, professional packaged, VERY quickly (2 weeks earlier than they said it would take), and just overall I love the company. I will be buying products for research in the future.
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Have already placed a second order and will return for many more!
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I’ve always had a fantastic experience with Truemeds.ca. Ordered from them probably half a dozen times now, every package is discreet and very good quality. Customer support is great. Hopefully they stick around and continue to offer more products.
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Speed was somewhat lacking but caliber of all other statistics more than made up for it. They’re 100% legit, and the materials are top quality. The real deal. All the other ones are just imitations and cheap knock offs. Even messed my address up, and order still arrived without a hitch to be seen. Thanks again! Will def be returning as sure as the sun sets.
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I’m supremely pleased. I live in a ruff area and got robbed so I haven’t ordered this month. I couldn’t get my cash to the bank. Sad I would have gotten at least 10 1cplsd usually 25 or 50. I’ve been using your service for the past year $thousands worth of research. Thank you.
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Good products, but really expensive.
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Thompson (verified owner) –
Speed was somewhat lacking but caliber of all other statistics more than made up for it. They’re 100% legit, and the materials are top quality. The real deal. All the other ones are just imitations and cheap knock offs. Even messed my address up, and order still arrived without a hitch to be seen. Thanks again! Will def be returning as sure as the sun sets.
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Materials arrived within 2 weeks to Midwest US. No issues, packaged well. So far products are reliable. Ordered more today.
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Pure product fast shipping.
Herrera (verified owner) –
My heart is broken… They no longer ship to the US. They are the only company I could trust, and they’re gone. It doesn’t make any sense, nothing changed in the states regarding law. They are a solid company. Please reopen shipping to the states.
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Highest quality. Exactly as advertised. Shipping was as fast as possible.
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Great customer service. There was an issue with the shipping address I provided so I emailed support. I figured if i were lucky someone would email back a week later or so. Within the next hour I had a response and after explaining the situation it was resolved quickly. A new updated receipt was even sent to confirm. I look forward to ordering from them again, theres no one else I’d trust for my research needs.
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Professional, quality vendor providing excellent service. I had a few questions and sent an email which was answered thoroughly and kindly in less than an hour! Packages have always been sent same or next business day, and arrived to the NE USA in less than a week. I’ve placed three orders now and Truemeds.ca has my full trust and support. Thank you folks.
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I love this company. Best ever hands down. I had a slight hiccup with payment and when I reached out to the team, they responded same day and took care of my issue ASAP. My order was shipped very fast and I received it very fast. This is the only company I trust with my research and will continue to support them. Thank you very much Truemeds.ca.
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I was surprised to receive a call back so soon. 10 out of 10
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website very easy to order and great prices.
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