Buy 3-CMC CRYSTAL Online
3-CMC, also called 3-Chloromethcathinone is a Research Chemical that belongs to the cathinone class. 3-CMC is seen as the replacement for 3-MMC. Since October 28, 2021, the well-known and popular 3-MMC has been on the opium list II, on this list are the soft drugs (such as hash and weed). The risks of these drugs are less great than the substances on list I, the hard drugs such as cocaine. Want to buy 3-CMC? We offer 3CMC in 3 variants: 3CMC crystals, 3CMC powder & 3CMC capsules. Buy 3-CMC CRYSTAL Online
3-CMC effects & 3-CMC experiences
3-CMC is a Research Chemical, which means that not much research has been done on the substance. The possible effects of 3-CMC and experiences you can experience with 3-CMC are:
– It has a stimulating effect
– It makes you feel confident
– It brings out euphoria and empathy
Important information when purchasing 3-CMC
– For sale only for research purposes
– Prevent the release of Research Chemicals into the environment
Synthetic cathinones represent one of the largest and most abused new psychoactive substance classes, and have been involved in numerous intoxications and fatalities worldwide. Methcathinone analogues like 3-methylmethcathinone (3-MMC), 3-chloromethcathinone (3-CMC), and 4-CMC currently constitute most of synthetic cathinone seizures in Europe. Documenting their consumption in clinical/forensic casework is therefore essential to tackle this trend. Targeting metabolite markers is a go-to to document consumption in analytical toxicology, and metabolite profiling is crucial to support investigations.
We sought to identify 3-CMC, 4-CMC, and 4-bromomethcathinone (4-BMC) human metabolites. The substances were incubated with human hepatocytes; incubates were screened by liquid chromatography-high-resolution tandem mass spectrometry and data were mined with Compound Discoverer (Themo Scientific). 3-CMC-positive blood, urine, and oral fluid and 4-CMC-positive urine and saliva from clinical/forensic casework were analyzed. Analyses were supported by metabolite predictions with GLORYx freeware.
Twelve, ten, and ten metabolites were identified for 3-CMC, 4-CMC, and 4-BMC, respectively, with similar transformations occurring for the three cathinones. Major reactions included ketoreduction and N-demethylation. Surprisingly, predominant metabolites were produced by combination of N-demethylation and ω-carboxylation (main metabolite in 3-CMC-positive urine), and combination of β-ketoreduction, oxidative deamination, and O-glucuronidation (main metabolite in 4-CMC-positive urine).
These latter metabolites were detected in negative-ionization mode only and their non-conjugated form was not detected after glucuronide hydrolysis; this metabolic pathway was never reported for any methcathinone analogue susceptible to undergo the same transformations. These results support the need for comprehensive screening strategies in metabolite identification studies, to avoid overlooking significant metabolites and major markers of consumption. Buy 3-CMC





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